Empyema complicating diseases other than pneumonia


(1) Secondary to septicaemia or pyaemia.—In patients with a generalized blood infection, the occurrence of pleural pain, dyspnoea or an unexplained deterioration in general condition should lead to a careful investigation for evidence of infection of the pleural space. Fortunately, these cases, which were often bilateral, are now rare, as the result of the widespread use of chemotherapy.

(2)    Empyema secondary to subphrenic abscess.—Reference is made above to Harley's review of 182 cases of subphrenic abscess (Harley, 1949), in which he found that empyema occurred in 29 per cent, but that 50 per cent of these cases followed injury to the diaphragm, caused by transpleural drainage, a penetrating wound or transpleural aspiration (Fig. 5). On the other hand, he found that a serous pleural effusion occurred in 25 per cent. This means that, if the diaphragm is uninjured, a pleural effusion arising in the course of a subphrenic abscess is more likely to be serous than suppurative, which emphasizes the importance of diagnostic aspiration in these cases. A serous effusion will clear up spontaneously provided that the subphrenic abscess is drained satisfactorily. An infected effusion should receive treatment similar to that described above for a post-pneumonic empyema. When the empyema is localized and ready for external drainage, the site for rib resection should be chosen by the method described above and sshould be separate from the wound made to drain the subphrenic abscess.
(3)    Empyema secondary to bronchiectasis.—If the infection associated with bronchiectasis extends into the lung parenchyma, the patient suffers an acute febrile episode,., usually described as pneumonia. In some cases, if the pleural space is not obliterated by adhesions, the infection spreads further and gives rise to an empyema. This possibility should not be forgotten because the diagnosis is apt to be missed, so that the empyema becomes chronic, and then, if a broncho­pleural fistula develops, the increased expectoration is attributed to an exacer­bation of the bronchial infection.
(4)    Empyema secondary to lung abscess.—If a foetid lung abscess ruptures into the pleural space, the patient often becomes dangerously ill within a few hours. In these cases the injection of penicillin into the stinking pyopneumo­thorax is often life-saving.
(5)    Empyema secondary to bronchiogenic carcinoma.—In patients of cancer age who develop an empyema, the possibility of an underlying growth should always be considered, particularly in males, and if the acute illness was preceded by a considerable period of lassitude or by symptoms of bronchial irritation. In cases of doubt, the patient should be subjected to bronchoscopy before deciding on treatment of the empyema. If a growth is found, the presence of the empyema does not exclude the possibility of successful resection. If there are other factors indicating that the growth is inoperable, every effort should be made to control the empyema by aspiration and intrapleural chemotherapy, so that external drainage may be avoided, for a discharging wound only adds to the miseries of a dying patient.
(6)  Empyema due to actinomycosis.—Infection of the pleural cavity by actino­
mycosis characteristically produces a thin layer of pus with much loculation,
but, exceptionally, a single cavity simulating a postpneumonic empyema occurs.
Infection of the pleura is often followed by much pain and later by induration of
the chest wall and sinus formation. Drainage operations are rarely required,
for almost all cases clear up completely and permanently as a result of prolonged
and intensive systemic penicillin therapy. It is suggested that at least 2,000,000
units should be given daily for a minimum period of 6 weeks.